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How does one argue for the impossibility of Epistemology from the theory-ladenness of observations? Explain different ways of answering such criticisms.

 Two forms of theory‐ladenness should be kept separate: (a) The semantic form: the meaning of observational terms is partially determined by theoretical presuppositions; (b) The perceptual form: the theories held by the investigator, at a very basic cognitive level, impinge on the perceptions of the investigator. The former may be referred to as semantic and the latter as perceptual theory‐ladenness.

In a book showing the theory-ladenness of psychiatric evidences, Massimiliano Aragona (Il mito dei fatti, 2009) distinguished three forms of theory-ladenness. The "weak form" was already affirmed by Popper (it is weak because he maintains the idea of a theoretical progress directed to the truth of scientific theories). The "strong" form was sustained by Kuhn and Feyerabend, with their notion of incommensurability.

However, Kuhn was a moderate relativist and maintained the Kantian view that although reality is not directly knowable, it manifests itself "resisting" to our interpretations. On the contrary, Feyerabend completely reversed the relationship between observations and theories, introducing an "extra-strong" form of theory-ladenness in which "anything goes".

Reasoning from observations has been important to scientific practice at least since the time of Aristotle who mentions a number of sources of observational evidence including animal dissection (Aristotle(a) 763a/30–b/15, Aristotle(b) 511b/20–25). But philosophers didn’t talk about observation as extensively, in as much detail, or in the way we have become accustomed to, until the 20th century when logical empiricists transformed philosophical thinking about it.

The first transformation was accomplished by ignoring the implications of a long standing distinction between observing and experimenting. To experiment is to isolate, prepare, and manipulate things in hopes of producing epistemically useful evidence. It had been customary to think of observing as noticing and attending to interesting details of things perceived under more or less natural conditions, or by extension, things perceived during the course of an experiment. To look at a berry on a vine and attend to its color and shape would be to observe it. To extract its juice and apply reagents to test for the presence of copper compounds would be to perform an experiment. Contrivance and manipulation influence epistemically significant features of observable experimental results to such an extent that epistemologists ignore them at their peril. Robert Boyle (1661), John Herschell (1830), Bruno Latour and Steve Woolgar (1979), Ian Hacking (1983), Harry Collins (1985) Allan Franklin (1986), Peter Galison (1987), Jim Bogen and Jim Woodward (1988), and Hans-Jörg Rheinberger(1997), are some of the philosophers and philosophically minded scientists, historians, and sociologists of science who gave serious consideration to the distinction between observing and experimenting. The logical empiricists tended to ignore it.

A second transformation, characteristic of the linguistic turn in philosophy, was to shift attention away from things observed in natural or experimental settings and concentrate instead on the logic of observation reports. The shift developed from the assumption that a scientific theory is a system of sentences or sentence like structures (propositions, statements, claims, and so on) to be tested by comparison to observational evidence. Secondly it was assumed that the comparisons must be understood in terms of inferential relations. If inferential relations hold only between sentence like structures, it follows that theories must be tested, not against observations or things observed, but against sentences, propositions, etc. used to report observations. (Hempel 1935, 50–51. Schlick 1935).

Friends of this line of thought theorized about the syntax, semantics, and pragmatics of observation sentences, and inferential connections between observation and theoretical sentences. In doing so they hoped to articulate and explain the authoritativeness widely conceded to the best natural, social and behavioral scientific theories. Some pronouncements from astrologers, medical quacks, and other pseudo scientists gain wide acceptance, as do those of religious leaders who rest their cases on faith or personal revelation, and rulers and governmental officials who use their political power to secure assent. But such claims do not enjoy the kind of credibility that scientific theories can attain. The logical empiricists tried to account for this by appeal to the objectivity and accessibility of observation reports, and the logic of theory testing.

Friends of this line of thought theorized about the syntax, semantics, and pragmatics of observation sentences, and inferential connections between observation and theoretical sentences. In doing so they hoped to articulate and explain the authoritativeness widely conceded to the best natural, social and behavioral scientific theories. Some pronouncements from astrologers, medical quacks, and other pseudo scientists gain wide acceptance, as do those of religious leaders who rest their cases on faith or personal revelation, and rulers and governmental officials who use their political power to secure assent. But such claims do not enjoy the kind of credibility that scientific theories can attain. The logical empiricists tried to account for this by appeal to the objectivity and accessibility of observation reports, and the logic of theory testing.

Francis Bacon argued long ago that the best way to discover things about nature is to use experiences (his term for observations as well as experimental results) to develop and improve scientific theories (Bacon1620 49ff). The role of observational evidence in scientific discovery was an important topic for Whewell (1858) and Mill (1872) among others in the 19th century. Recently, Judaea Pearl, Clark Glymour, and their students and associates addressed it rigorously in the course of developing techniques for inferring claims about causal structures from statistical features of the data they give rise to (Pearl, 2000; Spirtes, Glymour, and Scheines 2000). But such work is exceptional. For the most part, philosophers followed Karl Popper who maintained, contrary to the title of one of his best known books, that there is no such thing as a ‘logic of discovery’.(Popper 1959, 31) Drawing a sharp distinction between discovery and justification, the standard philosophical literature devotes most of its attention to the latter.

Although theory testing dominates much of the standard philosophical literature on observation, much of what this entry says about the role of observation in theory testing applies also to its role in inventing, and modifying theories, and applying them to tasks in engineering, medicine, and other practical enterprises. 

Theories are customarily represented as collections of sentences, propositions, statements or beliefs, etc., and their logical consequences. Among these are maximally general explanatory and predictive laws (Coulomb’s law of electrical attraction and repulsion, and Maxwellian electromagnetism equations for example), along with lesser generalizations that describe more limited natural and experimental phenomena (e.g., the ideal gas equations describing relations between temperatures and pressures of enclosed gasses, and general descriptions of positional astronomical regularities). Observations are used in testing generalizations of both kinds.

Some philosophers prefer to represent theories as collections of ‘states of physical or phenomenal systems’ and laws. The laws for any given theory are …relations over states which determine…possible behaviors of phenomenal systems within the theory’s scope. (Suppe 1977, 710) 

So conceived, a theory can be adequately represented by more than one linguistic formulation because it is not a system of sentences or propositions. Instead, it is a non-linguistic structure which can function as a semantic model of its sentential or propositional representations. (Suppe 1977, 221–230) This entry treats theories as collections of sentences or sentential structures with or without deductive closure. But the questions it takes up arise in pretty much the same way when theories are represented in accordance with this semantic account. 

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